A pronoun may sometimes be grammatically capable of referring to either of two nearby persons or entities. This produces uncertainty about the antecedent, not necessarily uncertainty about the dictionary meaning of the pronoun itself.
Suppose two people have been mentioned and the speaker then says, “He was angry with him.” Without additional context, the subject and object may be unclear. This is an illustrative language example, not a quotation from scripture.
A careful reader looks at the nearby nouns, grammatical agreement, earlier and later clauses, and the point of the discourse. Proximity of a noun may help, but it does not automatically establish the intended reference when the broader context points elsewhere.